Longevity Actives
Senolytic, senomorphic and geroprotector actives to license or co-develop
Plant-derived actives that target senescent cells and other hallmarks of aging, each with data on human skin models and patent protection.
The actives
| Active | Class · use | Key results |
|---|---|---|
| ZenoLase | Senolytic · skincare | Ex vivo adult human skin: senolytic activity +255%, collagen +94%, hyaluronic acid +484%, age-related inflammation −40 to −55%. 3D skin: melanin −38%. Clinical: non-irritating, non-sensitizing. Patent pending. |
| ReverZase | Senomorphic · skincare (also as a NAD+ complex) | Skin cells: about 75% reversal of senescence markers. Ex vivo aged skin: collagen +103%, less DNA damage. 3D pigmented skin (15 days): melanin −59%. Clinical: non-irritating. |
| DionySenz | Senolytic · supplements | Ex vivo aged human skin: senolytic activity comparable to the reference senolytics navitoclax and dasatinib + quercetin. Clinical: 10 days of oral intake improved skin hydration and radiance. |
| KronoZase | Geroprotector · supplements | Skin cells: raises intracellular NAD+, lowers inflammation and ROS, supports collagen and hyaluronic acid. Extended lifespan in C. elegans. |
Finished products built on these actives include ZenoLase Evanesce Prime Serum and THÉVASE ReverZase Regenerate Cream. Earlier versions of these products were a Top 3 finalist at Cosmetic Victories 2023 in Paris and won a Bronze Medal at the 49th Geneva International Exhibition of Inventions in 2024. See our products.
Intellectual property
The actives are covered by a PCT application on a natural senolytic formulation (PCT/TH2025/050028) and further Thai patent and petty patent filings on senolytic and geroprotector compositions. Plant sources and process details are shared under NDA.
Ways to work together
| Model | Who owns the IP | Best for |
|---|---|---|
| License | KronoLife keeps the IP; you license the active for your products | Fast launch with a proven active |
| Co-development | Shared IP in the new formula or active | A product or active built for your market |
| Transfer and license-back | IP transferred, KronoLife licensed back | Companies that want to own the technology |
What the active dossier contains
- Mechanism and the hallmark of aging it targets
- Efficacy by model: cells, ex vivo skin, 3D skin and clinical where available
- Safety data and recommended use level
- Specification, stability notes and formulation guidance
Common questions
Can we get a sample to test in our own formula?
Yes, after an NDA. We agree the evaluation plan with you so results are comparable to our data.
Are the actives available for supplements as well as skincare?
ZenoLase and ReverZase are developed for skincare. DionySenz and KronoZase are developed for supplements.
Can we commission new data for our market?
Yes. We can run additional studies on ex vivo or 3D skin, or plan a clinical study, through our testing service.
Evaluate a patented longevity active
Ask for the technical dossier under NDA: mechanism, efficacy by model, safety and use level.